Blar i forfatter "Bhandari, Sabin"

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    • Changes in the proteome and secretome of rat liver sinusoidal endothelial cells during early primary culture and effects of dexamethasone 

      Li, Ruomei; Bhandari, Sabin; Martinez-Zubiaurre, Inigo; Bruun, Jack-Ansgar; Urbarova, Ilona Halva; Smedsrød, Bård; Simon-Santamaria, Jaione; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-02)
      Introduction<p> <p>Liver sinusoidal endothelial cells (LSECs) are specialized fenestrated scavenger endothelial cells involved in the elimination of modified plasma proteins and tissue turnover waste macromolecules from blood. LSECs also participate in liver immune responses. A challenge when studying LSEC biology is the rapid loss of the in vivo phenotype in culture. In this study, we have ...

    • Molecular profiling of the liver sinusoidal endothelial cell – a multi-omics approach 

      Bhandari, Sabin (Doctoral thesis; Doktorgradsavhandling, 2021-08-20)
      The endothelium is the innermost cell layer of blood vessels and has a key role in maintaining vascular homeostasis. Beside the general role to prevent blood coagulation and regulate blood flow, endothelial cells of different vascular beds show tissue specific specializations. This thesis focuses on a unique endothelial cell with immune-like properties, namely the liver sinusoidal endothelial cell ...

    • The scavenger function of liver sinusoidal endothelial cells in health and disease 

      Bhandari, Sabin; Larsen, Anett Kristin; McCourt, Peter Anthony; Smedsrød, Bård; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-11)
      The aim of this review is to give an outline of the blood clearance function of the liver sinusoidal endothelial cells (LSECs) in health and disease. Lining the hundreds of millions of hepatic sinusoids in the human liver the LSECs are perfectly located to survey the constituents of the blood. These cells are equipped with high-affinity receptors and an intracellular vesicle transport apparatus, ...

    • Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages 

      Bhandari, Sabin; Li, Ruomei; Simon-Santamaria, Jaione; McCourt, Peter Anthony; Johansen, Steinar Daae; Smedsrød, Bård; Martinez, Inigo Zubiavrre; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-27)
      <i>Background</i> - Liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs; liver resident macrophages) form the body’s most effective scavenger cell system for the removal of harmful blood-borne substances, ranging from modified self-proteins to pathogens and xenobiotics. Controversies in the literature regarding the LSEC phenotype pose a challenge when determining distinct functionalities ...